Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics

Huntington’s disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical trial of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics, reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge testing of therapeutic strategies for HD. Chapters explore areas such as, normal huntingtin biology in brain development and function, genetic modifiers of HD in patients, molecular pathogenic mechanism in HD, and mechanisms underlying selective neuronal vulnerability

– Reviews the clinical course and genetics of HD
– Reviews the biology of human huntingtin and HD-relevant cell types
– Reviews the wide range of pathobiology associated with mutant huntingtin
– Reviews genetic studies of HD and how these studies are informing the development of new therapeutic approaches
– Reviews new tools and model systems for basic and translational research in HD, including new human-derived model systems, as well as systems biology and artificial intelligence–driven approaches
– Provides an overview of new therapeutic approaches and current clinical programs in HD

ASIN ‏ : ‎ B0CV7C2PSL
Publisher ‏ : ‎ Academic Press
Accessibility ‏ : ‎ Learn more
Publication date ‏ : ‎ February 7, 2024
Language ‏ : ‎ English
File size ‏ : ‎ 112.3 MB
Enhanced typesetting ‏ : ‎ Enabled
X-Ray ‏ : ‎ Not Enabled
Word Wise ‏ : ‎ Not Enabled
Print length ‏ : ‎ 596 pages
ISBN-13 ‏ : ‎ 978-0323956734
Page Flip ‏ : ‎ Enabled
Best Sellers Rank: #2,524,612 in Kindle Store (See Top 100 in Kindle Store) #445 in Physiology (Kindle Store) #1,626 in Physiology (Books) #1,740 in Neuroscience (Kindle Store)
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